Clemson vs Syracuse Prediction, Odds and Best Bet

• Undefeated No. 15 Syracuse visits No. 5 Clemson in an ACC showdown
• The Orange are 4-1 against the spread in their last five meetings with the Tigers
• Explore all the odds and our best bets for Clemson vs Syracuse below

Don’t look now Syracuse fans, but all of a sudden the Orange are 6-0 for the first time since 1979. Up next, an ACC showdown with the No.5 ranked Clemson Tigers in Death Valley. You won’t want to miss Clemson vs Syracuse on Saturday.

The Orangemen of Syracuse enter this one coming off of a defensive masterclass in a 24-9 victory over NC State.

Meanwhile, Clemson will be glad to play this one at home after a hard-fought 34-28 road victory over Florida State.

You can watch Clemson vs Syracuse this Saturday on ABC. Kickoff is slated for 12pm ET from Memorial Stadium. Until then read on for all the odds and our best bets.

Clemson vs Syracuse Odds

Odds as of October 19th at BetMGM Sportsbook.

Clemson enters this battle of undefeated ACC squads as a -13.5 favorite. The total is set at 49.5 for Clemson vs Syracuse in week 8. Currently, 86% of bets placed with the spread are on the Tigers at -13.5.

Clemson Betting Trends

After being anointed the next great quarterback after Trevor Lawrence left Clemson, DJ Uiagalelei failed to impress last season. Having said that, he’s turned things around this year and enters this week with 17 touchdowns and just 2 interceptions on the season. The junior signal caller is the centerpiece of Clemson’s offense, which now averages 424 yards and 38.6 points per game on the year.

This pocket movement from DJ Uiagalelei and then the 🚀 pic.twitter.com/dnBXt3PQHG

— Cam Mellor (@CamMellor) October 16, 2022

After a shaky start to the season, Dabo Swinney’s men will be looking to make a late-season push toward the College Football Playoff. Although, their path to the Playoff is far less straightforward than in past years.

The Tigers may be 7-1 against the spread in their last eight conference games, but the Orange have been a formidable opponent. Clemson is just 1-4 against the spread in their last four games versus Syracuse.

Syracuse Betting Trends

Syracuse enters this one riding high off a 24-9 smacking of NC State at a sold-out JMA Dome last weekend. Now, the Orange face their toughest test yet as they head to Death Valley to take on No. 5 Clemson.

Make that 6-0 for the Syracuse Orange 😤

We’ve been watching this Cuse offense all year, and these 3 have been ON it:

🔸Shrader: 1441 yards, 12TD – 3INT
🔸Tucker: 646 yards, 6TD, 28 MTF
🔸Gadsden II: 31rec, 507 yards, 5TD pic.twitter.com/cXshAEf7LU

— Redshirt Heisman (@TasteOfSport) October 19, 2022

The Syracuse Orange may have the most underrated defense in the country. Miraculously, the Orangemen enter this contest with the 8th-ranked defense in the nation, allowing just 312 yards per game. On top of that, Syracuse has surrendered just 15.8 points per game this season. Linebacker Mikel Jones was all over the field last week, leading the team with 7 tackles and key sacks on NC State’s final possession. He’ll be essential in stopping the explosive Tigers attack on Saturday. Co-ordinator Tony White’s defense must unleash chaos and limit mistakes for Syracuse to have any chance at victory.

The betting trends favor Syracuse in this matchup. The Orange have gone an almost unimaginable 5-1 against the spread this season. For a team whose goal was to play in a bowl game in 2022, the first six weeks of this season have to feel like a dream.

Clemson vs Syracuse Prediction

Historically, Syracuse has played Clemson very well. The Orange have come close to pulling off a historic upset on more than one occasion. Syracuse has won two of ten games in the all-time series, the first 41-0 at the Gator Bowl in 1996 and the most recent 34-3 at home in 2017. But in three of the past five matchups, they kept it close, including a three-point defeat in the Dome last year.

After witnessing the Syracuse defense dominate NC State last week, it’s tough to believe Clemson can beat this team by two scores. Take Syracuse to cover the 13.5-point spread.

Pick: Syracuse +13.5 (-110)